The phrase "a formidable challenge because" is correct and usable in written English.
It can be used when introducing a reason or explanation for why something is considered a significant challenge.
Example: "The project was deemed a formidable challenge because of the tight deadlines and limited resources."
Alternatives: "a significant obstacle due to" or "a tough task because of".
That is a formidable challenge because insulin is needed to maintain normal blood sugar.
The identification and study of adaptively important genes in forest trees represents a formidable challenge because of their long generation spans.
Modeling schizophrenia in animals represents a formidable challenge because the most characteristic symptoms of this disorder, auditory hallucinations and delusional beliefs, cannot be directly modeled in animals.
Soft-tissue reconstruction of large posterior heel ulcerations represents a formidable challenge because of the specialized nature of the tissues; relatively immobile surrounding tissues; proximity to underlying tendon, bone, and neurovascular tissues; and limited soft-tissue flap procedures available.
Describing the way the theme of pain has been approached in medical curricula in France over the last decade is a formidable challenge because of the dual, pluridisciplinary and pluriprofessional, organization of training programs.
The leapfrog strategy represents a formidable challenge because substantial or transformational innovation is needed and because getting established in a marketplace where a competitor likely has scale and momentum will be difficult.
Reconstructing molecular mechanisms in cancer on the basis of modules, networks, and complexes is a formidable challenge both because of the enormous numbers of components in interacting networks but also because of inherent difficulties arising from methodological imperfections.
Large healthcare databases covering a total population of over four million from three countries were investigated— a formidable challenge in itself because of the diversity in healthcare and disease coding practices.
However, guessing the environmental factors that have conferred an evolutionary advantage to strains carrying gene duplications presents a formidable challenge, more particularly because the real niche for S. cerevisiae is still a matter of debate, to the extent that S. cerevisiae may be considered a generalist that does not necessarily favor a specific type of environment (102).
Early stage breast cancers, such as low-grade ductal carcinoma in situ (DCIS) or lobular carcinoma in situ, which are detected by these methods, present a formidable challenge to oncologists, because only 5%to10%0% of patients with DCIS typically progress to invasive carcinomas [ 47- 51].
"Those involved in higher education have a formidable challenge in this country because the dead weight of the past is enormous," Dr. Gilman said.
