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The phrase "a formidable burden of" is correct and usable in written English.
It can be used to describe a significant or heavy responsibility, obligation, or difficulty that someone is facing.
Example: "The organization faced a formidable burden of debt that threatened its future operations."
Alternatives: "a heavy load of" or "a significant weight of".
Exact(3)
Applicants who claim they were victims of unjust treatment "bear a formidable burden of persuasion," the pardons office says on its Web site.
The partisan of the slippery slope thus has a formidable burden of argument to take up.
Stroke constitutes a formidable burden of disability for patients, their carers and the community in general and is the third leading cause of death worldwide [ 1].
Similar(56)
This potentially presents a considerable burden to patients, as well as a formidable administrative burden to hard pressed health care professionals.
Colorectal cancer is a common malignancy and remains a formidable health burden worldwide.
Panic disorder affects many people, is associated with a formidable disease burden, and imposes costs on society.
Their faces show the relief and lifting of once formidable burdens.
However, doctors are also facing a formidable barrier of high patient load due to inefficiencies in the health care system.
Hers was a formidable achievement of intellect and will.
Iraq had a formidable arsenal of chemical weapons.
This book is a formidable labor of six years.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com