These observations indicate that ESI treatment results in the production of a form of TCRα lacking N-glycosylation.
We previously reported a dominant negative effect for ΔDAG-Rasgrp1, a form of Rasgrp1 lacking the DAG-binding C1 domain (ΔDAG) and we postulated that there may be competition with the residual ∼10% of wildtype RasGRP1 (Roose et al., 2005).
In support of this model, inducing clustering of endogenous Crb by overexpressing a form of Crb lacking the intracellular domain is sufficient to overcome the loss of Spectrins and to suppress wing growth (Fig 5).
This study demonstrated, utilizing a form of Numb lacking two protein kinase C (PKC) phosphorylation sites, that inability to phosphorylate Numb results in the inappropriate accumulation of Numb at the cell membrane and unresponsiveness to PKC activation [ 54].
A rare form of lack of development, regarding a short tract of the müllerian ducts, leads to the isolated agenesis of the uterine cervix.
A rare form of lack of development, regarding only a tract of the müllerian ducts, leads to the isolated uterine cervix agenesis [ 1, 2].
Due to a point mutation, SMN2 predominantly produces a form of SMN that lacks exon 7, which is rapidly degraded.
Here, we describe the generation of mice that express a form of NRP1 that lacks the cytoplasmic domain (Nrp1 cytoΔ /Δ).
Here, we describe the generation of mice that express a form of NRP1 that lacks the cytoplasmic domain and, therefore, the SEA motif (Nrp1 cytoΔ /Δ mice).
These cells -- known by the name Hela, a shortened form of Lacks's name -- would become among the most used in the world, and were instrumental in vaccine development, gene mapping, cloning, and other areas of scientific research.
