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In Germany, the DRG system has led to considerable dissatisfaction, forcing hospitals to extremely tight personnel schedules, a forced increase in case numbers, a drastically heavier work load and a critical shortage of funding [ 32, 33].
If the lack of secretion by MP is due to inappropriately low pHi, then a forced increase of pHi should allow it to stimulate insulin release.
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Thus, due to the elasticity of the finger, the tangent surface would mechanically cause a force increase.
The folding rate or unfolding rate decreases or increases approximately exponentially upon a force increase in the narrow force range tested (Bustamante et al., 2004; Figure 5D).
We also find that a forced transient increase of intracellular macromolecular crowding (MC) or perturbation of CCR delays cell growth.
A general preservation of the forces transmitted through the facet joints was obtained; a minor force increase at the implanted level was detected.
Each colour, represented in the legend, denotes a different force increase in units of pNs−1.
The observed positive inotropic effect of 0.1 µM clenbuterol was partially attributed to myofiber hypertrophy and was confirmed in myobundles from multiple donors, resulting in an average force increase of 43.2 ± 10.8%.
Furthermore, as an alternative route to [Ca2+]m saturation, we forced an increase in the [Ca2+]m by overexpressing the MCU.
A recent paper [38] has reported a force-activated increase of the binding rate between integrins and ligands due to the hypothesized presence of catch bonds.
But government cuts of £90m to the OU in England have forced an increase.
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