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So, for example, in the USA, the Food Quality Protection Act provides legislated guidance on testing for cumulative effects by using the term 'common mechanism of toxicity' (481), which is interpreted to mean 'mode of action' or 'the major steps leading to an adverse health effect following interaction of a pesticide with biological targets'.
This would appear to be the case since allelic variants of ovine PrP associated with classical scrapie have a greater efficiency for in vitro conversion into a protease-resistant form following interaction with PrPSc [ 16, 84].
However, surface chemistry also matters – ash particles acquire a soluble salt coating following interaction with volcanic gases in the volcanic plume (Stewart et al., 2009).
The results described here may support the hypothesis that MAK5 directly activates macrophage activities in aged mice, whereas it only primes lymphocytes to display a greater immune response following interaction of splenic lymphocytes with another stimulus, such as Con A. Our findings suggest that MAK5 may contribute to the prevention of the immunosenescence.
SHM is required as a basis for the selection and proliferation of B cells expressing a BCR with a high affinity for antigen, following interaction with follicular dendritic cells [ 8, 9].
Although activity-based enzyme probes are widely used for in vitro and cellular studies, translation to in vivo imaging studies can be limited when the probe design lacks a method for cellular or tissue retention following interaction with an enzyme target.
Thus, subjects started with a representation of the structural form of the dynamics and subsequently parameterized this representation following interaction with a specific hammer.
We have analyzed ten human breast tumors stratified for ER status, following interaction with a manually deposited tamoxifen solution, as described previously [25, 26].
On the path to understanding the behavior of substrate-selective inhibitors, an additional mechanism was uncovered: following interaction with MK2, the activity of p38 with regard to ATF2 is substantially reduced.
Another case of acute renal failure in a 9-year-old child was recorded following interaction with tacrolimus [ 73].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com