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Similar results were obtained in a follow-up replication study.
The first stage involves a genome-wide association study of 1000 cases of schizophrenia-control pairs, with a follow-up replication study in another 1000 cases of schizophrenia and in 1000 controls, and combination analyses with groups from other places including China and Hong Kong.
A follow-up replication study was performed to validate the results of the initial phase with a second cohort of 598 unrelated Han Chinese subjects (Group 2) with equal number of cases and controls.
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Our findings herein lay a preliminary foundation for guiding follow-up replication studies, and eventually revealing the causal mutations underlying milk production traits in dairy cattle.
The wealth of this information calls for an integration of gene association data, evidence-based gene ranking, and follow-up replication in large sample.
Another 2,304 subjects were used for follow-up replication studies with selected markers.
Three additional white populations were used for follow-up replication studies: another independent cohort of CAD- and/or MI-affected families (GeneQuest II: 441 individuals from 22 pedigrees), an Italian cohort with familial MI (248 cases) and 308 Italian controls, and a separate Cleveland GeneBank cohort with sporadic MI (1,231 cases) and 560 controls.
We conducted a genome-wide association study on the number of melanocytic nevi reported by 9136 individuals of European ancestry, with follow-up replication in 3581 individuals.
We conducted a genome-wide association study on cutaneous basal cell carcinoma (BCC) among 2045 cases and 6013 controls of European ancestry, with follow-up replication in 1426 cases and 4845 controls.
We present a novel knowledge-based weighting framework to boost power of the GWAS and insightfully strengthen their explorative performance for follow-up replication and deep sequencing.
In the follow-up replication stages, 144 tests were performed in the independent UK families, 120 tests in the US families and 48 tests with the independent UK cases and controls.
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