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Three had anti-SSA and/or anti-SSB, but not a focus score ⩾1, while four had a focus score ⩾1, but not anti-SSA and/or anti-SSB.
Of the remaining three patients with Bm2+Bm2′/eBm5+Bm5 <5, only one had a focus score ⩾1.
The fourth patient had a focus score ⩾1, but the results of her unstimulated salivary flow were not available.
Minor salivary gland biopsy was performed, showing diffuse lymphocytic infiltrations with a focus score of 3 [ 8].
Within the AECG criteria, the 25 patients displayed anti-SSA and/or anti-SSB and/or a focus score ⩾1.
In two cases with a focus score 12, significantly higher numbers of CD19+ B cells (P < 0·01) were observed compared with CD3+ T cells (Fig. 1b).
Similar(44)
The positive cases are a total of the categories with a foci score of 1, 2 and 3. To assess the capacity of the DNA damage response (DDR) using a more comprehensive approach, we configured the DDR score by counting the total number of positive factors present in baseline foci of BRCA1, γH2AX and Rad51, and EC-induced foci of Rad51, per case.
Finally, IL-17 protein expression progressively increases with a higher focus score, indicating an expansion of the Th17 subpopulation in more severe phases of the disease [ 30].
Ectopic GC formation is associated with a higher degree of lymphoid sialadenitis – that is, with a higher focus score [ 6, 33] – and GC-like structures often coincide with focal periductal infiltrates [ 33].
Moreover, these mice developed sialadenitis with a mean focus score of 2.2.
For this purpose, a cumulative focus score (cFS) was evaluated on three slides cut at 200-μm intervals from each of a series of 120 salivary biopsies.
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