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We tested the ability of EF- and FPN-hNSCs to engraft and differentiate following transplantation in a focal model of demyelination induced with a single injection of lysolecithin in the corpus callosum of adult mice.
In addition, we calculated the likelihood of a focal model using AIC weights.
The ΔAICc statistic was calculated as the AICc difference between a focal model and that having the minimum AICc.
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This study has shown for the first time that anti-CD20 therapy reduces lesion development and extralesional microglial activation in an antibody-independent model of MS and a focal humoral model.
We first defined the time course of loss in spontaneous OR memory in both a transgenic mouse model of familial tauopathy, and a focal tauopathy model induced by injection of AAV containing a mutant tau cDNA.
Neuroprotection by ghrelin was demonstrated by Liu et al [ 34] in this 4-vessel occlusion model (see Table 1), and by Chung et al [ 35] in a focal ischemia model.
A focal reperfusion model of stroke was induced in conscious spontaneously hypertensive rats (SHR) by administering endothelin-1 to the middle cerebral artery via a surgically implanted cannula.
The permanent MCA ligation method which is also referred as pMCAo in the literature is used extensively as a focal ischemia model in rodents.
The first evidence for a neuroprotective effect of EPO by a peripheral route of administration was provided by Brines et al. (2000), who demonstrated in a focal stroke model a significant reduction in infarct volume by an intraperitoneally applied high dose of EPO (5000 IU/kg) up to 6 hours after reperfusion.
Model-fit values are presented as AIC value differences between the focal model and best model (labeled with *).
Finally, exposure to nanoalumina, but not to nanocarbon, increased brain infarct volume in mice subjected to a focal ischemic stroke model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com