However, null findings were observed in a recent study of a flaxseed-derived lignan supplement (500 mg/day) on lipid profiles in 22 healthy women [14].
Several randomized controlled studies showed beneficial effects of a flaxseed-supplemented diet (30 50 g/day) on lipid profiles in both normal- and hypercholesterolemic subjects [6] [10].
The study aimed to investigate the effect of a flaxseed-derived lignan supplement on glycemic control, lipid profiles and insulin sensitivity in type 2 diabetic patients.
The objective of the study was to investigate the effect of a flaxseed-derived lignan supplement on indexes of glycemic control, insulin resistance and lipid profiles in type 2 diabetic patients.
We showed that 12-week supplementation of a flaxseed-derived lignan complex, which provided 360 mg/day SDG, statistically significantly reduced HbA1c concentrations in type 2 diabetic patients as compared with the placebo.
In agreement with previous studies [14], [33], we found that a 12-week supplement of a flaxseed-derived lignan providing 360 mg/day of SDG did not affect blood lipid profiles, insulin resistance, fasting glucose and insulin concentrations in type 2 diabetic patients.
Therefore, we evaluated the effect of a flaxseed-derived lignan supplement (containing 360 mg/day SDG, equivalent to 27 60 g of whole flaxseed [20]) on indexes of glycemic control, insulin resistance and lipid profiles in a randomized, double-blind, placebo-controlled, cross-over study.
In conclusion, this microarray study of lung tissues from mice supplemented with a flaxseed-diet has provided unique insights into the genes that were modulated in the mouse genome secondary to the presence of flaxseed, a botanical wholegrain with potent anti-inflammatory, antioxidant, and anti-fibrotic properties.
