The phrase "a flat dose of" is correct and usable in written English.
It can be used in contexts related to medicine or pharmacology, typically to describe a specific, unchanging amount of a medication or substance.
Example: "The doctor prescribed a flat dose of 500 mg of the medication to be taken daily."
Alternatives: "a fixed dose of" or "a standard dose of".
In the treatment of advanced renal cell carcinoma, temsirolimus is administered as a 30- to 60-minute infusion once weekly at a flat dose of 25 mg.
Irinotecan was administered either alone or in combination with cisplatin as a 90-min continuous intravenous infusion at a dose level between 175 and 350 mg m−2 or at a flat dose of 600 mg.
In a phase II trial of OC treated with weekly intravenous injection of temsirolimus at a flat dose of 25 mg, objective responses were observed in only 9.3% of patients (5 of 54), and the 6-month progression-free survival (PFS) rate was 24%, causing the study to fail to meet its efficacy endpoint [25].
44 In the cohort with indolent non-Hodgkin lymphoma, patients were randomly assigned to receive obinutuzumab at a flat dose of 400 mg on days 1 and 8 of cycle 1 and on day 1 of cycles 2 8 (400/400 mg) or a dose of 1,600 mg on days 1 and 8 of cycle 1 and 800 mg on day 1 of cycles 2 8 (1,600/800 mg).
Unlike other antidepressants, SSRIs demonstrate a flat dose response curve for the treatment of depression with higher than standard doses (>1 DDD) being of questionable benefit [ 29- 31, 36, 37].
As SSRIs demonstrate a flat dose response curve for the treatment of depression with 1 DDD representing a therapeutic dose [ 18, 29- 31, 36, 37], the outcome variable of prescribed daily dose was dichotomised as a binary outcome variable of ≤1 or >1 DDD i.e. those with a standard therapeutic dose versus those with a higher dose.
A mathematical algorithm was developed, using the simulated pristine dose profiles as its input, to calculate the weight of each pristine peak, reproduce the SOBP, and finally generate a flat dose distribution.
Ribavarin is a purine nucleoside analogue and can be given weight based or a flat dose.
Sirolimus was administered at a single oral flat dose of 5 mg per day continuously in an outpatient setting.
All patients received all three treatments (day 1, 8, and 15) at the single flat dose of 160 mg per formulation.
Several reports have shown that weight-based dosing of RBV is more effective than flat dosing of RBV, and that adequate dosing of RBV is crucial to maximising HCV treatment response [ 18, 19].
