Selective oestrogen receptor modulation (SERM), a concept first recognised in the laboratory in the mid-1980s [ 11, 12], advanced the first agent, raloxifene, to prevent osteoporosis with breast cancer and endometrial safety.
Postweaning multisystemic wasting syndrome (PMWS) is a disease of pigs first recognised in Canada in 1991 that now is a global epizootic [ 1- 3].
Legionnaires' disease, a form of severe pneumonia caused by a Gram negative aerobic intracellular bacteria, was first recognised during an American Legion convention in Philadelphia in July , 1976 [1.
However, there can be no doubting a talent which was first recognised through his performances for CSKA Sofia, for whom he made his debut at 18.
It is really a Nietzschean refashioning of Euripides's Bacchae (albeit set in 12th- century Sicily), and Szymanowski himself adapted the ending of the libretto to portray a man who has first recognised and then overcome the dangerous, yet enriching, Dionysian forces within.
The existence of convection in double-diffusive systems, in which heat and salt diffuse at a different rate, was first recognised in the late 1950 s.
The concept of a breast clinician was first recognised during the Edinburgh and Guildford Pilot Programme.
Hypothyroidism as a clinical syndrome was first recognised in the 1870s and its subsequent treatment with extract of animal thyroid was first achieved in Newcastle upon Tyne during the 1890s by Murray[ 4].
A possible modification mechanism that could explain at least one of the additional peaks would be shortening of the side chain by β-oxidation, a pathway which was first recognised by feeding experiments with synthetic ω-phenyl fatty acids [ 58].
Buchner et al. first recognised a non-linear relationship between leg strength and usual gait speed; this relationship explained how small changes in physiological capacity may have substantial effects on performance in frail adults, while large changes in capacity have little or no effect in healthy adults [ 61].
In addition, like Lennon and McCartney, Martin had come to fully appreciate Harrison as a songwriter, later saying: "I first recognised that he really had a great talent when we did 'Here Comes the Sun.' But when he brought in 'Something,' it was something else … It was a tremendous work – and so simple".
