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The fossil record suggests a first occurrence of the black bear lineage at least 1.8 Ma Kurténn and Anderson 1980).
A Cox model was used to identify the correlates of a first occurrence of a major CADE.
The paper focuses on patients with a first occurrence of stroke admitted to the rehabilitation clinic after the acute care at a stroke unit.
Likewise, for women with a first occurrence of pre-eclampsia in their third pregnancy, the risk was 14.7% during the fourth pregnancy.
Similarly, for women with a first occurrence of pre-eclampsia in their second pregnancy, the risk was 15.9% during the third pregnancy; and 29.0% during the fourth when they had developed pre-eclampsia in the previous two pregnancies.
Capecitabine doses were reduced by 20% for patients who experienced a first occurrence of a grade 3 haematological toxicity, a second occurrence of grade 2 non-haematological toxicity or any grade 3 non-haematological toxicity.
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The drug was discontinued in case of a second occurrence of severe toxicity.
If a second occurrence of >grade 1 toxicity occurred, sunitinib was further reduced to 12.5 mg.
At a third occurrence of >grade 1 toxicity, sunitinib was discontinued.
Afatinib was discontinued after a third occurrence of AEs as specified above.
The patient discontinued volasertib after a second occurrence of DLT (grade 4 thrombocytopenia) at 300 mg.
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CEO of Professional Science Editing for Scientists @ prosciediting.com