The results in this work demonstrate the validity of the proposed methodology and its consistency with the results of a second methodology based on the Overlap measure, a metric that has been used in many works found in the literature to evaluate segmentation schemes.
This motivated a second methodology for calling significant CNV using individual CGH probes.
These changes were then validated in a second independent cohort of twenty three patients using a second methodology.
A second methodology under development is a computer modeling technique called quantitative structure activity relationships, or QSAR.
We sought to confirm a subset of our findings with a second methodology, and concurrently investigate potential reasons for the discordance between our MS-HRM findings and reported literature.
Finally, a fourth methodology is employed by Pathway Distiller (11), which mines 2462 pathways from six pathway databases, and subsequently unifies them into clusters of several predecided sizes between 5 and 500, using hierarchical clustering.
Although the results just described are generally consistent across the range of most plausible values (Kukic et al., 2013), namely 2 to 6, we sought to confirm our conclusions with a second methodology.
Using a second methodology, antigenic chimeric viruses have been generated by replacing the membrane protein (M) and E structural genes of rDEN4Δ30 with those from DEN-2 or DEN-3 [ 12, 15].
To verify that the deviation from the expected 50% methylation was not due to PCR bias or other artefacts, we developed a third methodology specifically to accurately quantify the levels of methylation.
