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The phrase "a first complication" is correct and usable in written English.
It can be used when introducing an initial issue or challenge in a discussion or narrative.
Example: "In the process of developing the software, a first complication arose when we encountered unexpected bugs in the code."
Alternatives: "an initial issue" or "a primary challenge".
Exact(1)
Excluding late histological stages, an adverse outcome was documented for 20/185 (10.8%): 15 UDCAeated/5 UDCA (P = 0.15), comprising a first complication in 14 10 untreated/4 UDCA (P = 0.40), liver transplantation in 4 3 UDCAeated/1 UDCA(P=0.64) and liver-related death in 2 (both untreated, P = 0.51).
Similar(59)
A third complication relates to vowel usage in the phylum: most Afro-Asiatic languages do not indicate vowels within their written documents.
A second complication occurs during reentry to the atmosphere, when the unpowered RV is subject to relatively unpredictable forces such as wind.
There Mr. Viot became a Breguet specialist, designing and making a prototype moon-phase with tourbillon for the Swiss brand, before creating a second complication including a perpetual calendar, tourbillon and minute repeater.
Now we introduce a second complication.
As a second complication, Oscar's transition from English to Twin English is not entirely clean-cut.
A third complication caused by GERD comes from microscopic changes that make the lining of the esophagus more like the lining of the intestine.
A second complication arises from the fact that most hospital pathogens are bacteria frequently carried asymptomatically.
Twelve days after that, a second complication of the initial operation occurred.
A second complication is that the diagnostic accuracy of the tests is usually determined through the comparison of the index test results with those of a reference standard.
A second complication arises from the initiation energy Φ I that describes the entropy necessary to bring the two molecules into contact.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com