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These findings provide a first clue of the complex biological processes affected by the drug both on a quantitative and on a qualitative basis.
Initially, immunoreactive, ubiquitin-positive neuronal inclusions were identified in ALS and FTLD and provided a first clue of a shared pathogenic mechanism between these conditions.
Reproducible "permanent heterozygosity" in sequence data - initially obtained from most of the analyzed individuals of the A. gambiae complex species using primers placed on flanking regions of AgAcp34A-2 (Table 1) - provided a first clue of the putative presence of a genomic duplication.
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This observation could provide a first clue on the function of photosynthesis in this strain, if we assume that additional energy generated from light is required for the efficient utilization of certain substrates with a low energy yield.
This is particularly noteworthy as it is a first clue for the influences of fast stress reactions independent of the second wave.
This result was surprising, because proteasomal degradation should result in total decomposition of GFP-CL1 and provided a first clue for the degradation of the CL1 degron sequence by autophagy since the GFP part remains and is not, or only slowly, degraded by vacuolar proteases.
Our study demonstrates for the first time the expression of alternative splice variants in gastric carcinomas and provides a first clue to a role of survivin-2B in tumour progression.
A first clue for a functional role of this tumour specific downregulation became evident when comparing the expression levels of the proapoptotic TRAIL-variant with the non-proapototic isoforms (TARIL-β and -γ), showing a tumour specific increase of proapoptotic TRAIL-α.
This observation provides a first clue for understanding the independence of translatome changes by the transcriptome: following cell stimuli which act on their expression, many genes coding for components of the translational machinery do not undergo any change in their mRNA levels, but only variations in the rate of polysomal loading of these mRNAs.
With condition-specific expression patterns providing a first clue to the role that some of these ncRNAs may play, a further functional analysis will help to better understand the intricate details of ncRNA-mediated gene regulation allowing bacteria to adapt to different and alternating environmental conditions.
Buried a mile and a half beneath that X is the first clue of a scavenger hunt that will lead to the free-speech zones.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com