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The width parameter w of the cone is uniquely determined by the height of the segment and the radius of the sphere, which models the bottom joint: Figure 4 Building a finger model from quadrics.
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The various case studies were performed for a unit finger model considering different loading conditions.
To provide kinematic and kinetic inputs for the tendon network model, a multisegment finger model was constructed.
In the present study, to provide a basis for designing ATFs that can regulate the human A20 gene, a ZFP sequence involving six contiguous Cys2His2-type zinc fingers was constructed using the classical Cys2His2-type zinc finger model and an 18 bp DNA sequence (as target sequence) obtained from the A20 gene promoter region.
The index finger model is developed using a commercial software package AnyBody, and it contains seven muscle/tendons that connect the three phalangeal finger sections.
To simplify the modelling process, some noteworthy assumptions were employed in the multisegment finger model and in the tendon network model.
After data processing, the measured external load P and the phalanx angles θ1, θ2, θ3, and θ4 at a representative instant of time were used as inputs to the multisegment finger model and the tendon network model for in vivo force calculation.
Finally, numerical simulations of the finger pulling up the tab of the can end has also been performed and discomfort in the fingertip has been related to the maximum value of the contact stress of the finger model.
Using the muscle forces estimated by the multisegment finger model, the tendon network model was then used to calculate the forces transmitted along each tendon component.
The 3D finger postures and the external forces at the fingertip during static pressing by one healthy male subject (age: 25, weight: 75 kg, height: 1.72 m) were measured to provide kinematic and kinetic inputs for the finger model.
For DNA-binding specificity predictions, sequence logos and position frequency matrices (PFM) were obtained by entering the reference and SNP individual zinc finger sequences to the ZFModels website (stormo.wustl.edu/ZFModels) (Gupta et al. 2014) using the parameters ZF Protein Sequences, One Finger Model, and Information Content.
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