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Finally, combining this new replication in a final meta-analysis together with the five original GWASs and the two ' in silico' replications yields an OR of 0.88 (95% CI 0.85 to 0.91; P = 4.4E-11), which exceeds the accepted threshold for testing multiple comparisons (that is, P < 5E-8).
A final meta-analysis was performed combining all independent samples from these three groups with the SCORM study of Asians aged <25 years.
Controlling the confounding factors in a final meta-analysis involving populations from different countries could pose problems, but "the 'before and after' nature of the individual studies should certainly provide meaningful results at the population level," he says.
A final meta-analysis and Forest plot for the marker rs1562990, including the five original GWASs plus the two ' in silico' replicas and the final replica, was done with the Stata 10.0 (College Station, TX, USA) metan command.
A final meta-analysis included one RCT and one cohort study that compared letrozole + gonadotrophin versus gonadotrophin alone: the pooled pregnancy rate per patient was not significantly different (OR = 1.40; 95% CI 0.67 2.91).
A final meta-analysis of 21 controlled studies showed that psychosocial interventions did not impact any form of psychological distress but the meta-analysis for pregnancy rate was significant with sub-group analysis showing increased pregnancy rate but only in patients undergoing non-ART treatments [ 18].
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45 46 We included 10 reports on nine different trials in the systematic review (supplementary figure A). 7 8–14 47 One report was not included in the final meta-analysis as it was a secondary trial report and the only one providing five year follow-up data.
The 22 studies included in the final meta-analysis enrolled a total of 807 patients, with an average of 37 patients per study [ 23- 44].
Seven studies were included in the final meta-analysis, covering a total of 9697 T1DM cases and 8455 controls.
45 46 We included 10 reports on nine different trials in the systematic review (supplementary figure A). 7 8 9 10 11 12 13 14 47 One report was not included in the final meta-analysis as it was a secondary trial report and the only one providing five year follow-up data.
A total of four RCTs (n = 178) were identified for final meta-analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com