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Yet, a final differentiation into mature adipocytes containing large, fused lipid vacuoles was not achieved.
As a final differentiation, this work is not directed at a specific biological issue--although some biological predictions are presented and an investigation of a redundant pathway is included in Additional file 4--rather, it addresses what will be necessary to progress the modeling of complex biologic processes.
Although DWI of pleomorphic adenomas and myoepithelial adenomas could be distinguished from malignant tumours, a final differentiation between benign and malignant parotid gland tumours based on ADC values was not possible because of an overlap between Warthin's tumour and malignant lesions.
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They extend long membrane protrusions that make cell cell contact with mature cells, while exercising a capacity to delay their final differentiation until a local demand materializes.
In an attempt to resolve some difficulties associated with this concept, Mikkers and Frisen [ 27] described the development of a cell along a certain lineage as a linear process with a gradual specialization through determination, commitment and final differentiation.
Alternatively, plasmablasts can be derived from TD responses and are the GC derived precursors of the long-lived plasma cells that undergo a round of cell division before final differentiation [ 23].
One key finding is that stem cells divide continually and generate a "stock" of committed progenitor cells that do not terminally differentiate right away but postpone their final differentiation for long time intervals in the absence of a local epithelial cell loss.
Although TGF-β1-induced LC-like cells, E-cadherin triggering induced final differentiation into LCs with a phenotype similar to primary isolated LCs.
In a review by Amir et al. [ 31] it was speculated if tension stress during distraction inhibited final differentiation of chondrocytes and rather trans-differentiated these cells into osteoblastic cells.
Because its expression rapidly wanes prior to final differentiation, neurogenin-3 must activate a gene expression program that then completes the differentiation of these cells.
This final differentiation step is characterized by a lengthening of the pNB cell cycle, loss of MIRA expression and a reduction of cell size (Maurange et al., 2008).
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