Sentence examples for a fibroblastoid shape from inspiring English sources

hAFSC, before injection, present a fibroblastoid shape as shown in Figure 1A.

Cells showed a fibroblastoid shape.

In addition, and resembling the results obtained with MCs, MLECs from Cav1−/− mice had a spindlelike morphology in ex vivo culture (Fig 7D) and acquired a fibroblastoid shape when treated with TGF-β1 in combination with IL-1β, a costimulation known to induce full EMT in HPMCs (Yanez-Mo et al, 2003; Strippoli et al, 2008).

Fibroblastoid shape and adhesion to plastic are recognized criteria to characterize a stem cell population, but others cell types like monocytes and endothelial cells maybe contaminants ASC preparations [ 21].

The essential characteristics of EMT are the disruption of tight cell cell contacts, and acquisition of a fibroblastoid spindle-shape morphology, with increased invasiveness and cell stroma interactions, as well as slower rates of cell division; altogether, these can result in the release of single cells from a solid epithelial tumor.

Transforming growth factor-β1 (TGF-β1), one of potent and well-studied cytokine, has been shown to alter the morphology of A549 cell line from cobblestone shape to elongated spindle shape, a fibroblastoid appearance [ 5– 8].

EMT requires loss of epithelial polarity and epithelial specific proteins, induction of a fibroblastoid phenotype and of mesenchymal markers, and acquisition of a migratory phenotype [12], [25], [26].

In this study, we hypothesize that Pyk2 transformed HCC cells to a fibroblastoid phenotype through regulation of genes associated with EMT.

Of particular interest, experiments conducted to silence the expression of E-cadherin not only showed a morphological shift from an epithelial to a fibroblastoid phenotype, characteristic of EMT, but also a concomitant increase in invasive cell behavior [5].

Marshall cell (MC), a fibroblastoid rat mammary tumor cell line (BICR-M1Rk) which expresses only Connexin43 (Cx43) was cultured in DMEM supplemented with 10% FCS and 1% penicillin-streptomycin as described [15].

Mesothelial cells lose their basolateral and basoapical polarity, acquiring a fibroblastoid phenotype with migration capacity.