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The phrase "a few significant" is correct and usable in written English.
It can be used when referring to a small number of important or noteworthy items, events, or factors.
Example: "There are a few significant changes in the policy that we need to discuss at the meeting."
Alternatives: "several important" or "a handful of notable".
Exact(60)
There are a few significant differences, though.
This prejudice rules out more than a few significant figures.
As structures, Northwest Coast houses shared a few significant traits.
The galleries have reopened with most of their familiar sights and a few significant changes.
There have been a few significant privacy cases where damages have been awarded.
Since then, the romance novel has undergone a few significant changes.
A few significant media outlets did their own coverage of the rumor.
Fourth, the committee concluded that in a few significant instances, the analysis in the N.I.E.
Even some longtime political experts say they see only a few significant differences between the candidates.
I think the answer can be yes, with a few significant caveats.
The polling evidence — with a few significant caveats — says "possibly, yes".
More suggestions(21)
in a few significant ways
a few remarkable
a few important
a few vital
a few prominent
a few notable
a few noticeable
a few momentous
a few large
a few sizable
a few considerable
a few huge
a few substantial
a few major
a few tremendous
a few noteworthy
a few salient
a few sizeable
a couple of significant
a few sensitive
a slight significant
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com