Sentence examples for a few common variants from inspiring English sources
Most of those diseases turn out to be caused not by a few common variants, as many biologists expected, but by an unmanageable number of rare variants, offering for the most part no clear target for drugs or diagnosis.
Should most of the genetic component of the disease turn out to depend on multiple rare variants, the task of finding general treatments might seem to be far harder than if a few common variants were involved.
These reports have essentially ruled out the likelihood of a few common variants conferring the majority of SZ heritability.
In contrast, rare mutations of larger effect and a few common variants of small effect in several different genes, which are also involved in different cellular pathways, seem to be causal for many cases of AD.
We therefore conclude that the enormous increased risk of AVSD in infants with DS is not caused by a few common variants of large effect, as we originally hypothesized.
There are a few common variant alleles in BRCA2 in Poland; one of these (C5972T) changes the amino acid sequence of BRCA2 from threonine to methionine at codon 1915.
One of the main assumptions of current GWAS is that common diseases are caused by at least a few common genetic variants of relatively large effect (the common disease, common variant [CDCV] hypothesis).
A few common modifying variants could have a large effect size on CHD in a trisomic background while having little or no effect in a euploid individual.
Our data show that a few common genetic variants of large effect size (odds ratio >2.0) do not account for the elevated risk of Down syndrome−associated atrioventricular septal defects.
Nevertheless, the 16 loci identified in European-derived white individuals together account for only 10% of the total genetic risk of GV in that group, indicating that additional loci probably remain to be discovered, with a few common and perhaps numerous rare variants accounting for disease risk at each locus.
The common disease/common variant (CD/CV) hypothesis proposes that common diseases are usually caused by one or a few common disease susceptibility alleles.
