In conclusion, the association of paclitaxel, vinorelbine and infusional 5-FU shows favourable activity and toxicity profiles and it may provide a suitable therapeutic option in advanced breast cancer patients pretreated with anthracyclines.
The title compounds 3e and 3g exhibited favourable activity against tobacco bacterial wilts in vitro compared to the commercial bactericides Kocide 3000.
Certain associations showed, in contradistinction to the separately applied components, surprisingly favourable activity.
Interestingly, rapalogues have also been shown to have favourable activity in triple-negative breast cancer cells [ 70].
The favourable activity was attributed to the inhibitory activity of thiol-modified HA on cell attachment, spreading, and proliferation, with the compound being negatively charged, hydrophilic, and lacking peptidic epitopes that activate integrins.
The favourable activity observed for the doublets of topotecan plus cisplatin and topotecan plus gemcitabine paralleled our ex vivo results for the three-drug combination in NSCLC specimens (unpublished observations).
The pathologic complete-response rate in evaluable patients for whom surgical information was known was 44% (16 out of 36), which is indicative of favourable activity (Abad et al, 2012).
This strategy has the advantage that crystallization screens sample a wide range of solution conditions in which the proteases may have more favourable activities.
Many AMPs have also shown to possess favourable activities other than bactericidal effect, such as anti-inflammatory properties (Auvynet and Rosenstein 2009; Bowdish et al. 2005; Scott and Hancock 2000).
Daptomycin is not only primarily (78%) excreted unchanged in the urine but also shows a favourable in vitro activity against Gram-positive uropathogens [ 6], making it an ideal candidate to treat severe urinary tract infection (UTI).
