As shown in Figure 5(A), D-Asp induced a fast time-dependent influx of Ca2+, which saturated at 3 min. As expected, removal of extracellular Na+ ions prevents the D-Asp-induced Ca2+ influx.
As depicted in Figure 1(A), inclusion of 1 mM Glu induced a fast time-dependent increase in Ser-2448 mTOR phosphorylation, reaching a maximal value at 15 min. No apparent changes in mTOR levels were observed in this condition.
For estradiol-17β-glucuronide a fast time-dependent efflux with similar efficiencies from SER and RER but no clear protein-mediated uptake was shown, indicating an asymmetric transport system for this substrate.
Heteromeric XtKir4.1/XtKir5.1 channels exhibit similar macroscopic current properties to rat Kir4.1/Kir5.1 with a faster time-dependent rate of activation.
In order to increase the antibody concentration in the brain, we chose the intranasal route of delivery which circumvents the BBB and leads to a fast time- and region- dependent distribution of applied molecules in the brain [36], [38].
On a fast time scale, we have a frequency dependent Moran process within each of the groups.
In conclusion, our study indicates that the pronounced and fast, time-dependent decrease in histologically defined infarct volume can compromise results when studying the lasting neuroprotective effects of potential drugs.
Using NO imaging in brain slices we recently demonstrated NOS2-dependent astroglial NO production, which occurred on a fast time scale (seconds) and did not involve de-novo protein synthesis [8].
I knew I had a fast time".
However, they will have a fast time course because of the fast τm.
Fig. 1A and B show that oocytes expressing heteromeric XtKir4.1/XtKir5.1 generated inwardly-rectifying K+ currents similar to those obtained with rat Kir4.1/Kir5.1, but which showed a significantly faster time-dependent component of activation at hyperpolarizing potentials (XtKir4.1/XtKir5.1 τ = 0.26 ± 0.09 s, rat Kir4.1/Kir5.1 τ = 2.01 ± 0.04 s).
