In mismatch repair-proficient HCT116+ch3 cells, degradation of p53 protein by E6 resulted in a 1.9±0.2-fold 1.9±0.2-foldsensincreaseto aminosensitivity±s.d., n=3, P<0.05 by a too-sided t-test).
Compared to Cy3-based fluorescence, silver amplified gold nanoparticle probes provide for a ∼1000-fold ∼1000-foldn sensincrease
However, the S. cerevisiae strain bearing the P. falciparum hybrid synthetase showed a 1,000-fold 1,000-foldn sensincreaseto cladosporin (IC50 from >200 μM to 0.17 μM, Figure 5C).
Long-Evans rats and Han/Wistar rats exhibit a 1000-fold dinference in sensitivity to acute TCDD lethality [ 15] which is attributed to a point mutation in the AhR protein of Han/Wistar rats [ 16].
In our experience, three rounds of amplification permits a 2000 to 4000-fold increasensitivitytivity as compared to traditional western blotting detection, while maintaining 100% specificity [17], [28].
The combination of RT-LAMP with the dengue IgM and IgG ELISA resulted in a significant increase (p < 0.001) in sensitivity to 97.7% (167 of 171) in comparison to using dengue IgM and IgG ELISA alone which had sensitivity of 70.8% (121 of 171).
The results from the only study (van den Broek 2006) that directly compared a Type 2 test and a Type 4 test were consistent with the meta-analytic finding and also demonstrated a statistically significant difference (P < 0.001) in sensitivity (Appendix 4).
The setup criteria (101.2 in absolute sensitivity and 10−7.5 in sensitivity density) of the lower limit of relatively high-sensitive elements are indicated by thick lines.
When compared to an assay targeting the ssrA gene, which encodes for tmRNA, an approximate 1000-fold increasensitivitytivity of detection was observed.
In our experience, three rounds of amplification permits an approximate 4000-fold increasensitivitytivity as compared to traditional western blotting detection, while avoiding both cross-contamination and generation of any spontaneously formed protease-resistant PrP, thereby maintaining 100% specificity [13].
