The phrase "a fall in leptin" is correct and usable in written English.
It can be used in contexts discussing biology, nutrition, or health, particularly when referring to changes in leptin levels in the body.
Example: "Research indicates that a fall in leptin can lead to increased appetite and weight gain."
Alternatives: "a decrease in leptin" or "a drop in leptin levels."
Fasting and cool temperatures induce β3-mediated sympathetic activation of white adipose, resulting in a fall in circulating leptin [32] [34].
Reducing daily caloric intake by 500 kilocalories resulted in a 5-10% decrease in body weight, decreased BMI, and a 25% fall in leptin plasma concentrations [ 25].
If caloric intake is further restricted by 600-1000 kcal/day, bodyweight decreases between 7 and 12%[ 25, 33] resulting in a 46-58% fall in plasma leptin levels and an increase of 42-65% in adiponectin levels[ 25].
In studies of cachectic cancer patients, the role of leptin appears more complex since the fall in leptin concentrations which accompanies a loss of body fat appears not to be associated with an improvement in energy balance (Simons et al, 1997; Wallace et al, 1998).
We also see an immediate effect of a calorific load, with a fall in risk-aversion dependent upon baseline leptin levels.
Firstly, a fall in bone active adipocyte hormones (oestrogen and leptin) following bariatric surgery may initiate bone loss.
Percent change in leptin tended to be inversely correlated with food intake (r=−0.62, P=0.058): a rise in leptin was associated with lower intakes at the ad libitum lunch test meal.
The weight of interscapular BAT was increased (p<0.001) in leptin-deficient mice (wild type 0.31±0.02, ob/ob 0.80±0.04 g/100 g body weight).
AGRP and NPY decrease after ADX despite the fall in plasma leptin and insulin concentrations which in other situations would increase these neuropeptides.
In 1998, a second mutation conferring a congenital deficiency in leptin was described in three individuals from a consanguineous Turkish pedigree [15].
