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Does the famine and food crisis reflect a failure of development?
And does the current news agenda – streaming coverage of worldwide youth disaffection – reflect a failure of development?
Single atrium is a failure of development of the embryologic components that contribute to the atrial septal complex.
It usually occurs in conjunction with microtia, which is the malformation of the auricle due to a failure of development of the external ear.
In what other joint formation has there been a failure of development from a primary developmental fault of part of a structure?
Loss of ESET or Oct4 results in strikingly similar phenotypes both in ES cells with their differentiation into trophectoderm cells, and in early embryos where there is a failure of development of the pluripotent inner cell mass (ICM) of blastocysts.
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Reduction of PTHLH's expression to very low levels prevented mammary gland development, and genetic disruption of this gene results in a failure of mammary development in mice and humans [ 54].
Perturbation of central signaling pathways, e.g., suppression of the nuclear factor kappa B (NF-kB), disrupts airway-branching and impairs development of epithelial, mesenchymal, and endothelial cell structures culminating in a failure of lung development [81 83].
The perturbation of central signaling pathways by the described inflammatory response is linked to the disruption of airway-branching and impaired development of epithelial, mesenchymal and endothelial cell structures, culminating in a failure of lung development as shown in fetal mice [14,15].
Further studies using phenotypic and transplantation analyses of mice carrying the mesenchymal dysplasia allele of patched 1 (Ptch1(mes)) revealed a failure of gland development, post-pubertal ductal elongation and delayed growth with ductal hyperplasia in these mice [ 30, 31].
Is it a failure of my development?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com