Sentence examples for a failure of circulating from inspiring English sources

A failure of circulating leptin to reach its target receptor within the brain appears to be one mechanism at work in rodents with diet-induced obesity, a classic model of leptin resistance.

161 The identity of the underlying mechanisms of leptin resistance still remains unclear, but at least three possibilities have been postulated to underlie it: (1) a failure of circulating leptin to reach its targets in the brain; (2) a decrease in the expression of LEPR; and/or (3) an inhibition of the signaling events within selected neurons in specific brain regions.

Alternative explanations that must be considered include 1) the potential failure of circulating prorenin to reach relevant targets within the heart, 2) the potential failure of mouse prorenin to stimulate the rat (pro renin receptor, and 3) potential downregulation of the cardiac (pro renin receptor in the presence of high-circulation prorenin levels (30).

In the context of end-stage heart failure, levels of circulating catecholamines may be extremely high, whilst they are diminished within the tissues especially the myocardium [5].

The lack of a sickness response to FK565 and MDP alone was paralleled by a failure of these NOD agonists to significantly augment circulating cytokine levels 3 h after injection.

This could be explained by a failure of effectively control T cell activation since a defective suppressive function of circulating Treg has been shown in WG patients [12].

We hypothesized that circulating IL-6 filtered by the glomerulus would remain in the urine due to a failure of proximal tubule metabolism.

A failure of democracy.

A failure of coordination?

Is it a failure of leadership?

Is it a failure of my development?