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The results suggested that the Natto peptide caused a failure of cell separation after cell division.
Significantly, a failure of cell abscission has also been reported in cultures in which γ-tubulin had been silenced [39].
Previously, we showed that CagA-induced cell elongation resulted from a failure of cell retraction and was not dependent on the RhoGTPases, Cdc42 and Rac1 [8].
However, in a previous report, our lab showed that CagA-induced cell elongation in cultured human gastric cells results from a failure of cell retraction, a process typically modulated by Rho activity at the trailing edge [8], [9].
The enamel knots of EdaTa embryonic teeth are simply smaller in than those of WT mice [16], while Edardl-J mutant molars have a structure termed the 'enamel rope' which is composed of enamel knot cells that are extended across the tooth primordium due to a failure of cell condensation [17].
mTOR-deficient progenitors show a failure of cell cycle re-entry.
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Mutation or deletion of these proteins leads to a failure of cells to arrest cell cycle progression in the presence of DNA damage and manifests itself as a profound loss of cell viability [2] [8].
This decrease in gene expression in aplnrb mutants may reflect a failure of cells to reach the APLM during development.
Further, embryos lacking Aplnr signaling did not contain cells in the heart-forming region of the ALPM, suggesting a failure of cells to reach this location.
Our identification that perturbed androgen action in the developing Leydig cell lineage leads to a failure of Leydig cell maturation and perturbed function, associated with late-onset degeneration of spermatogenesis in mice and Leydig cell apoptosis in both mice and humans, is an important finding that may have implications for men during aging.
In humans, mutation of FOXP3, a specific transcription factor for nTreg cells, will cause a failure of nTreg cell development and will subsequently cause X-linked immunodeficiency syndrome IPEX (X-linked syndrome, immune abnormality, polyendocrinopathy, enteropathy) [ 116].
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