Notably, normal cells typically respond in a facile manner to "correct' DNA damage responses once the test agent has been removed.
We noted that though maleimides react in a facile manner with thiol nucleophiles, maleamic acids do not (see ESI †).
N-arylated mono- or bisthio-maleimides can be assembled in a facile manner at pH 6 but hydrolyse rapidly at pH 8 yielding conjugates which are non-cleavable.
We believe that if DARPins could be selectively functionalised in a facile manner, a number of useful applications would ensue, e.g. a novel route to the linking of DARPins with different binding domains to construct bi-, tri- or multi-specific constructs, or functionalisation with a PEG chain and a cytotoxic drug to construct a targeted therapeutic.
This research combines modest IR imaging capabilities with the exceptional topographical imaging of conventional AFM to provide advantages of both in a facile manner.
Moreover, since RNA agents and hydrophobic anticancer drugs can be simultaneously loaded onto the surface and inner cores of this HDz nanocarrier, respectively, in a facile manner, this nanocarrier can exert synergistic effects associated with codelivery of these two different therapeutic avenues.
In this work, we present a straightforward method based on nanoindentation that allows the evaluation of flexoelectric properties in a facile manner.
14, 15 Nonetheless, each ligand is able to effectively distinguish self from non-self in forming different-sized circular assemblies and the components are able to exchange in-and-out of the circular helicates in a facile manner.
"We've learned that governing is not an easy task, and it can't be done in a facile manner".
To further enhance the performance of the DSSCs, hierarchical structures were formed with TiO2 quantum dots (QDs) in a facile manner.
1-D nanostructures provide large electrode-electrolyte interface for the reaction to take place in a facile manner.
