Richter's series September, and numbered "series No 911" in his internal cataloguing system, grew from a notebook drawing – an extrapolated mutation of who knows how many other mutated images – that he considered abstract until his friend, the art historian Benjamin Buchloh, looked at it and said: "Oh, that's the World Trade Center being attacked".
To support approval of an extrapolated indication, a biosimilar sponsor may need to demonstrate that the biosimilar has the same mechanism of action, target-binding characteristics, pharmacokinetics, and biodistribution in the clinically tested and the extrapolated indications, as well as address any expected differences in toxicity or effectiveness.
Then, light propagation distribution φ (r, t ) in Eq. (1) can be solved for a semi-infinite medium with an extrapolated zero boundary condition when either a pulsed laser [ 14] or continuous wave light [ 15, 16] is utilized.
By contrast, rat liver glycogen had a much less marked inhibitory effect, causing an extrapolated maximal inhibition of only 44%, with an IC50 of 90 ± 16 mM.
By introducing an extrapolated impulse response technique, a first attempt successfully reduced the arithmetic complexity of FIR filter from o(N) to o(√2N) comparing with direct form.
This cell count was divided by a factor of 0.08, to yield an extrapolated RGC density per unit area of cells/mm.
This solution (Eq. (3)) involves an extrapolated zero boundary condition including an isotropic source at z = z0 and negative isotropic imaging source at z = − z0 + 2zb).
A 2-fold less concentrated sample would generate an extrapolated result of 0.082, more than 2.5 fold lower than the cut-off value, and lower than the mean negative tissue OD of 0.137.
However, with BAGEL, for each gene, the ratio data from all the hybridizations involving the reference and test species are used to estimate a relative hybridization level for each species, including an extrapolated value for the reference species [ 37, 38].
AUC integration from zero to infinity was done by the sum of a trapezoidal integration of the measurement range (AUC0 288 h) plus an extrapolated model fit for the extrapolated range (AUC288 h ∞).
