The retention of the cytotoxic gemcitabine diphosphate (dFdCTP) in cells with a terminal elimination time as long as 72 h is probably a major factor determining this property.
CYP2C9*3 allele is associated to a longer elimination time of tenoxicam.
Retinal toxicity was hypothesized due to reduction of the preretinal space; the drug is confined to the limited aqueous-filled space surrounding the oil bubble and has a longer elimination time.
Studies with aprikalim, pinacidil, or nicorandil showed a comparable or better cardioprotection level but failed in clinical practice due to a long elimination time and systemic hypotension [ 13].
Cyclic polymers above the renal threshold of 30 kDa had a significantly longer elimination time (between 10 and 33% longer) than did the comparable linear polymer (for the 66 kDa cyclic polymer, t1/2,β = 35 ± 2 h) and a greater area under the serum concentration versus time curve.
Even a moderate, but sustained, improvement in the relative SIA coverage for the under-vaccinated subpopulation by 0.05 (from 0.2) leads to a slightly greater reduction of elimination time than a single expanded age group SIA round, with 58 days earlier WPV1 elimination achieved in the model.
In biliary excretion-deficient male rats lower bile flow was associated with a 2.5-times longer MeHg elimination time than in control animals [ 21].
The expanded age group scenario in Figure 3a shows the expected benefit of vaccinating all ages if these rounds attain the same improved coverage in the under-vaccinated subpopulation, with a shift in WPV1 elimination time of almost 1 year (Table 4).
Because of the CT colonography procedure time is approximately 20 minutes [ 23] an opioid with a rapid onset and short elimination time would be suitable and prevents long recovery times.
A substantial reduction in the elimination time occurs for WPV3 in the scenarios we explored for Bihar (top of Table 3) but not for WUP (bottom of Table 3) even in the case of SIAs expanded to all ages.
