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Briefly, FREGENE was used to simulate whole-genome sequence data in a population with an effective size (Ne) of 25 900 and a genome size of 50 Mb split equally over 10 chromosomes.
We modelled a hundred microsatellite loci in a population presenting an effective size estimated as described in the following paragraph.
A mutation causing a per allele effect of 0.25% would become completely fixed in a population with an effective size of 5 million individuals in 6000 selection events.
"Afghanistan is about the size of France, which is an effective size for a country," said Thomas Barfield, an anthropologist at Boston University, who has lived with nomadic Afghan tribes.
A base population with an effective size of 1000 was simulated for 4000 generations.
Initially a historical population with an effective size of 200 (Ne = 200) was simulated using QMSim [ 17].
The most conservative targets deemed necessary to maintain long-term genetic security of a species range from an effective size of 500 5000 (Franklin and Frankham 1998; Lynch and Lande 1998).
The ideal populations had an effective size of 500, a 1 1 sex ratio and a mutation rate of 10−8 per base pair per meiosis.
This model assumes that the African and European populations diverged 128,430 generations ago from an ancestral population with an effective size (Ne) of 1,705,328.
The second immigrated population underwent a bottleneck for a total of x years and has an effective size NNOR at the time of admixture.
Gadomer-17 has a MW of 17 kDa with an effective size nearly that of plasma albumin.
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