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Metingear provides a dynamic annotation system (Supplementary Table S1) allowing each entity to hold multiple annotations of the same type.
Because GenBank functions mainly as a deposition library – and not as a dynamic annotation interface – development of such an interface would enhance the ability to keep genome data current.
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Once genomic sequences are publicly released, they are dynamically annotated by HOMD (dynamic annotation).
We carried out a statistical analysis of the dynamic annotation information in different genomic regions, including the exonic regions, intronic regions, 3'UTRs, and 5'UTRs.
In our experience, soliciting contributions is essential to a dynamic community annotation project.
merlin's dynamic annotation tool was used to perform first an automatic re-annotation of the complete genome followed by a manual curation of the enzymatic annotation.
The back-end of Genome Explorer is a searchable annotation database that integrates all the results generated from the dynamic annotation pipeline mentioned.
We call this technique dynamic annotation inference.
Of the 747 genomes listed, 50 have dynamic annotation, 477 have static annotation and the remaining are in progress.
Currently available tools include Genome Viewer, Dynamic Annotation, BLAST, Annotator, EMBOSS, KEGG pathways (27), Gene Ontology Tree (28), Genomewide ORF Alignment and Sequence Download.
Currently the downloads include the following six primary categories: (i) Taxon tables; (ii) 16S rRNA gene sequences; (iii) Genomic sequences and dynamic annotation results; (iv) Genome meta informaton; (v) Database schema and (vi) Database table structures.
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