Sentence examples for a dual hit from inspiring English sources

PD might then target the PD-ICA network due to a dual hit effect of pathology superimposed upon normal aging.

An explanatory hypothesis for the occurrence of the described neutropenia-related events while combining ifosfamide with sunitinib might consist of a dual hit.

More recently, evidence has supported a "dual hit" theory which postulates that the original injury occurs early in lung development before and not connected to aberrant development of the diaphragm (Keijzer et al. 2000).

Although the RBD, enriched in carbohydrate and with low protein, has been used in several studies to induce malnutrition [ 27, 28], our study is the first to evaluate a dual hit of RBD-induced malnutrition and osmotic diarrhea, along with the role of zinc as a gut-trophic nutrient to improve intestinal inflammation, intestinal bacterial translocation, and intestinal morphology.

Recently, a so-called "dual hit" hypothesis has been proposed for Parkinson's disease (PD); this theory postulates a simultaneous involvement of the olfactory system and the DMNV, following aerosolic exposure to an unidentified pathogen which spreads to the ENS after swallowing [ 10].

Intriguingly, the dual hit hypothesis seems to fit well with a more general theory that could include prions.

The idea of dual hit in the RAS is not novel.

Dual hits 7, 8, 11 have comparable affinities for 5-HT3R and H4R, while dual hit 9 has 500-fold selectivity for 5-HT3R over H4R, and hit 10 has 200-fold for H4R over 5-HT3R (Table 1).

In addition, these novel findings could match with the "dual hit" hypothesis formulated by Braak for PD [ 10].

The dual hits of increased intracellular K+ influx from activated Na+, K+-ATPase and decreased K+ efflux from defective Kir channels potentiates the serum hypokalemia that upsets membrane polarization and muscle excitability in TPP (46).

First, with this hypothesis in mind, let us consider that huα-syn undergoes anterograde axonal transport from the OB in our paradigm (see Fig.  9), a notion consistent with the dual-hit hypothesis [ 31].