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The distribution showed a bimodal peak, with a drop in frequency at ±200 bp from the TSS.
Moreover, the deviation from neutrality of the AR3 population was not due to changes of frequency in the expected direction, since there was a drop in frequency of the putatively selected allele.
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At the end of the study, the women reported a drop in the frequency and intensity of their hot flashes.
The analyses revealed low levels of precipitation and a drop in the frequency of tropical cyclones from 800 to 900 A.D. in the Yucatan peninsula--which suggests the region was hit by a major drought at the time, the researchers told The Huffington Post in an email.
This drop in potency was also accompanied by a drop in the frequency of positive neutralizing sera to 6 out of 12 sera (50%) in the HVTN 041 trial and to 16 out of 21 (76%) in the DP6-001 trial (Fig 3D).
Further, there was a drop in the frequency of longer motifs in the five nematode genomes.
During this period, the TW2 population underwent a drop in the frequency of the putative hitchhiking allele, leading to a significant decline in heterozygosity over this period.
Suppression of LFP activity was accompanied by almost complete suppression of neuronal firing with a drop in MUA frequency from 5.5 ± 2.3 s−1 to 0.1 ± 0.1 s−1 (Fig. 2A).
Tumor resection in our experimental system led to a drop in DTC frequency below detection limit already one week post-surgery (the first time point analyzed) and from then on.
In our case, fixation of the host allele is more likely than fixation of the parasite allele because for our parameter combination and initial condition, it is usually the host that first experiences a Lotka-Volterra bottleneck and consequentially a drop in the frequency of one of the alleles (see also Figure 4).
Alternatively or additionally, surveillance interruption may have led to a drop in the frequency of preventive care procedures affecting all patients, such as daily sedative interruptions and spontaneous breathing trials that could account for the observed changes in population-level outcomes as well as the increase in VAP rates [ 6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com