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This argues for a driver role for demethylation deregulation in the development of these tumors.
This suggests a driven rather than a driver role of the IR zone in VF dynamics in this model.
The TRAF1-ALK fusion has been reported in three cases of ALCL (one in [ 40] and two in Abate et al., manuscript under review) suggesting a driver role.
Mutations related to lipid metabolism were mainly shared by the three samples analysed by WES, suggesting a driver role for this pathway.
Owing to the massive amount of information derived from these studies, it is often difficult to get an overview of the genes that play a driver role in cancer on mutation (cancer genes).
Additionally, miRNAs, which are located in a genomic region showing recurrent genetic aberrations, may themselves play a driver role in breast carcinogenesis or contribute to a driver gene in their vicinity.
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Finally, a number of supporting evidences point to a potential driver role for at least some of our novel lncRNAs.
Manor insist the signing of Fabio Leimer to a reserve driver role does not mean Roberto Merhi is in danger of losing his seat.
Sources say he is tired of F1, feels he is finished with it and, as things stand, is unlikely to try to find a reserve driver role to keep his foot in the door.
Finally, certain miRNAs themselves are located in genomic regions, which frequently show genetic aberrations, implying that these miRNAs themselves may have a potential driver role or contribute to known drivers in these genomic regions.
We found that SYK knock-down significantly decreased viability and growth rates in SYK/FYN-positive SCLC via increased cell death, suggesting that SYK plays an oncogenic driver role and that inhibitors could potentially be used in SYK-positive SCLC, alone or in combination with chemotherapy.
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