Behaviour has been traditionally viewed as a driver of subsequent evolution because behavioural adjustments expose organisms to novel environments, which may result in a correlated evolution on other traits.
Furthermore, we also tested for possible differentiation in parasite communities infecting the species in sympatry, which we hypothesized could be a driver of divergent evolution at the MHC.
On the other hand, we favor the hypothesis that KSHV tumorigenesis is the culmination of multiple complex interactions between the virus and its host, and lytic replication as a driver of clonal evolution and systems dysfunction, as outlined in our model, constitutes but one aspect of this dynamic and complex process.
Hybridization between distant genera is a driver of genome evolution and new species formation.
In that respect, apoptosis would be a driver of tumor evolution and a hallmark of aggressive disease.
Alterations in PPP2R5E have also recently been shown to be a driver of clonal evolution in breast carcinoma [ 7].
Notably, a STAG2 mutation was identified as a driver of clonal evolution from myeloid dysplastic syndrome to secondary acute myeloid leukemia [ 24].
However, this does not mean one should discount CUB as a driver of eukaryotic evolution, as previously argued (Waldman et al. 2010).
Further, the conservation of these splices sites in L1 families known to be currently active in the mouse genome strongly implies that generation of L1-exonized transcripts is ongoing, and thus represents a driver of transcriptome evolution.
More generally, Hao et al. [ 5] raise the intriguing possibility that DH-DC could be a driver of gene evolution in prokaryotes, one that has thus far gone undetected.
