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It is unclear at the moment if this is feasible in the sense that we don't know if a T7 enzyme will be functional using such a drastically modified primer.
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However, it is still an open question whether this distinction can be drawn, or whether there is a more gradual transition from selecting an explanatory hypothesis from a familiar domain (selective abduction) to selecting a hypothesis that is slightly modified from the familiar set and to identifying a more drastically modified or altered assumption.
In 1874, construction of a major shipping channel drastically modified the Lakes Huron Erie Corridor connection.
Finally, the configuration of the terminal station has been drastically modified to include a new generation of error-correcting codes as well as an appropriate modulation format.
The selection of topics was drastically modified from that of a traditional physics course, with some time-honored topics omitted or de-emphasized (e.g., projectile motion, relativity), and others thought to be more relevant to biology introduced or emphasized (e.g., fluids, dynamics).
Jones always sang weird songs and always seemed to be operating in a parallel entertainment industry universe where the rules were drastically modified to accommodate his considerable gifts.
It's not always a requirement that our favorite seasonal comfort food recipes be drastically modified to make them healthier (and unrecognizable).
The districts submit annual budgets to the central government for approval, after a review process in parliament funds are then disbursed, often drastically modified.
However, in the case of an unmagnetized e-p plasma [43], the drift velocities had drastically modified the solitary structures by reducing the soliton width.
The river's natural contour has been drastically modified and its ecosystem radically altered.
Transmission electron microscopy (TEM) of oriented serial sections showed that the perinuclear region corresponding to the MTOC was drastically modified upon IAV infection (Fig. 1c, d).
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