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The interaction is accompanied by a drastic side-chain flipping of Rab1 Gln70 towards GDP-AlF3.
Assistive devices such as wedge insoles are often prescribed as a less drastic, side effect-free treatment option.
— Is it humane for trainers to race horses on Lasix that do not bleed and thereby subject these animals to the drastic side effects of this powerful drug in order that some impaired horses might benefit from it?
It'd be real nice if you can get cured and no drastic side effects.
GraphSAW provides comprehensive drug-related knowledge and an improved medication analysis which may support efforts to reduce the risk of medication errors and numerous drastic side effects.
The drastic side-chain movement of Rab1 Gln70 towards GDP-AlF3 and therefore serving as the catalytic cis-glutamine is unexpected.
In addition, it was established that substitution at the 2 position of the cyclohexyl skeleton and, more importantly, an increase in steric bulk at that point, led to a drastic reduction of side product formation (i.e., methyl- and methylenecyclopentane).
A surgeon not involved in the Toga study, Dr. Philip Schauer, director of bariatric surgery at the Cleveland Clinic, called the new operation very promising and said that so far it seemed to offer "a drastic reduction in side effects and risk".
A narrowing of the subjects that are to be used in the evaluation of a school's performance will hit schools from one side, and a drastic reorganisation of the exam itself will hit them from the other.
Most notably, Glu452 in the Rab1-GDP-AlF3 complex now bears a strong hydrogen-bond or ionic interaction with Gln70 in Rab1, and this interaction renders a drastic conformational change of the side chain of Gln70.
In the Guardian last week my revered and reverend colleague Giles Fraser pitched in on the church's side but with a drastic demand for a "Beeching" cull of churches.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com