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The phrase "a drastic setback to" is correct and usable in written English.
It can be used to describe a significant hindrance or obstacle to progress in a particular situation or project.
Example: "The unexpected funding cuts represented a drastic setback to the research team's efforts to develop a new vaccine."
Alternatives: "a significant blow to" or "a major hindrance to".
Exact(1)
World War II caused a drastic setback to the breed, with the vast majority of breeding stock destroyed because of the hardship.
Similar(59)
While Paul Salem is correct in that "regionally, Aoun's election would be a victory for Iranian influence in the Levant and a blow for Saudi Arabia," it is important to understand and measure the extent of this blow and to assess whether it is indeed a drastic blow to Saudi Arabia's influence, or merely a symbolic setback.
The ruling today represents a significant setback to that strategy.
Youth unemployment is a major setback to sustainable growth.
The threat of Ebola in West Africa is still a major setback to the socioeconomic development.
One P. falciparum adaptation that represented a significant setback to malaria control efforts was the acquisition of CQ (chloroquine) resistance.
"It looks to be quite a setback to the industry".
"This is a setback to all emerging satellite businesses.
It is a setback to all minorities in the country.
It was an early setback to Chinese economic reforms.
Now Manuel is ready to make a drastic change to solve the bullpen conundrum.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com