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While control cells or cells incubated with DMSO alone lacked eGFP expression, cells incubated with 10µM IDV showed a drastic induction of eGFP (Figs. 2B and 2C).
This stress response is predominantly controlled by a transcription factor named heat shock factor 1 (HSF1) and is hallmarked by a drastic induction of heat shock proteins (HSPs) (Lindquist, 1986; Morimoto, 2008).
This frequency may have been underestimated in previous studies because we observe a drastic induction of proliferation of BM CD8+ T cells by BrdU itself, a base analogue used to identify DNA-synthesizing cells among CD8+ T cells.
For species in the grass family, there was a drastic induction of the PHAS loci in certain reproductive organs, such as the flower of foxtail millet, ear and tassel of maize (Zea mays), and panicle of sorghum.
Within model lignocellulolytic aerobic fungi, e.g., A. niger and T. reesei, growth on lignocellulosic biomass causes a drastic induction of cellulolytic and lignocellulolytic enzymes from almost undetectable transcriptional levels on glucose-grown cultures, to ≈12 20 % of the overall mRNA [ 24, 25].
This overall pattern of transcriptional change, or lack thereof, is quite distinct from the scheme utilized by aerobic lignocellulolytic fungi (e.g., Aspergillus niger and Trichoderma reesei [ 24, 25]), where growth on lignocellulosic biomass causes a drastic induction of cellulolytic and lignocellulolytic enzymes from low, almost undetectable transcriptional levels on glucose.
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Under ER stress, the accumulation of unfolded or misfolded proteins in the ER triggers the unfolded protein response (UPR), marked by drastic induction of a number of UPR genes including GRP78 and GRP94 via transcriptional activation [7].
Drastic induction of their expression at the transcriptional level was observed in cells infected with coronavirus.
During the course of studying the gene expression profiles in cells infected with coronaviruses, it was noted that drastic induction of many virus-inducible genes occurred at the transcriptional level.
More drastic induction of these genes implied that the transgenic plants might synthesize higher levels of polyamines to prevent them from lethal injury and maintain better growth under water stress [ 39].
At 24 h post infection, SA1 infected tissue showed drastic induction in inflammatory genes expression, which is associated with infiltration of neutrophils and alveolar macrophages.
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