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The phrase "a drastic change of" is correct and usable in written English.
It can be used to describe a significant or severe alteration in a situation, condition, or state.
Example: "The company underwent a drastic change of leadership after the CEO resigned unexpectedly."
Alternatives: "a significant shift in" or "a major transformation of".
Exact(47)
The third section provided a drastic change of mood.
The uneasiness that took root encouraged Dr Lee to try a drastic change of tack.
This new model would involve a drastic change of thinking by players and owners.
"We need a drastic change of the present situation," Mr. Baz told reporters after he met with Secretary Powell.
Last Monday, he retreated from his ad and released a public letter that expressed what seemed to be a drastic change of viewpoint.
Then in 2000 he carried out a drastic change of strategy in picking the Most Beautiful Girl and Nigeria's next international representative.
Similar(13)
The future is here – not in the shape of Facebook, Twitter and all the rest, but in a drastic change to one of civilisation's basic requirements: getting humans from place to place.
A drastic change in numbers of undergraduate and graduate students occurred between 1930 and 1934 during the Great Depression.
During this beginning period of CMRP, a drastic change in the color of the medium, from purple to dark brown-green, is observed, consistent with the suggested change in oxidation state of the cobalt complex.
However, after incubation with either GTP-loaded Arf1 or Arf6, we consistently observed a drastic change in the shape of many of the liposomes.
Alteration of the aromaticitiy in the terminal heterocycles of selected dications reveals a drastic change in the toxicity of these polyaromatic species toward specific cell lines.
More suggestions(20)
a strong change of
a considerable change of
a drastic shift of
a substantial change of
a vigorous change of
a drastic alteration of
a serious change of
a tremendous change of
a sharp change of
a drastic modification of
a radical change of
a sweeping change of
a far reaching change of
a drastic inhibition of
a drastic amount of
a drastic degradation of
a drastic shortage of
a drastic overhaul of
a useful change of
a drastic loss of
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com