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The phrase "a drastic alteration" is correct and usable in written English.
It can be used to describe a significant or severe change in a situation, object, or concept.
Example: "The company underwent a drastic alteration in its management structure to improve efficiency and communication."
Alternatives: "a significant change" or "a major modification."
Exact(16)
Without a drastic alteration to lifestyles, the prospect of another 200m Americans bodes ill for our suffering planet.Stephen PsallidasNewcastleSIR – You miss one exception to Europe's falling fertility.
We have recently demonstrated that through a sol gel route, superconductor crystallization in the presence of simple biopolymers results in a drastic alteration of morphology, producing technologically useful nanowires and porous architectures.
The second string revolution, which begin around 1995, has led to a drastic alteration in our perception of the universe, perhaps even more so then did the first string revolution of 1984.
The appeals court's broad interpretation of the Family Educational Rights and Privacy Act to apply to peer grading "would effect a drastic alteration of the existing allocation of responsibilities between states and the national government in the operation of the nation's schools," Justice Anthony M. Kennedy wrote for the court.
[s]elective and voluntary settlement programmes are believed to be the only viable options in the long run; as this change goes beyond a change of location for pastoral people and entails a drastic alteration in their cultural life, settlement will be conducted over a long period of time with the aid of training and initiative work (SDPRP 2000).
It in particular states that [s]elective and voluntary settlement programmes are believed to be the only viable options in the long run; as this change goes beyond a change of location for pastoral people and entails a drastic alteration in their cultural life, settlement will be conducted over a long period of time with the aid of training and initiative work (SDPRP 2000).
Similar(44)
As a result of his work on the chlorination of oils, waxes, and the like, Dumas proposed a "Law of Substitution," stating that hydrogen atoms (electropositive) could be substituted by chlorine or oxygen atoms (electronegative) in certain organic reactions without any drastic alteration in the structure.
In contrast, GMR-GAL4-driven expression of vertebrate A-Myb or c-Myb caused a similar drastic alteration in eye phenotype.
The heating phase beyond the critical temperature may become more viscous which indicates a rather drastic alteration of the nanofluid rheological properties leading to hysteresis.
Barring any drastic alterations, he'll likely lead the lead again in minutes played and distance covered, but those figures come with the risk of potentially preventing Chicago from getting where it so desperately wants to go.
But he's silent about a more voluntary, if no less drastic, alteration: the shearing away of the Kerr character's 8-year-old son in favor of a lurid backstory of sterility brought on by her husband's infidelity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com