All these genes displayed moderate to high expression levels in the control tumors, but after a total of 6 hours of hyperoxic treatment their expression was dramatically diminished, with a down-regulation ranging from 5 33 times in the individual tumors.
Treatment with anti-HLA-I antibody, but not with anti-HLA-II, dramatically diminished the cytotoxicity of Ad-CM-CTLs against NCI-H522 cells.
These findings thus demonstrate that STAT1 expression is dramatically diminished or lost in a significant proportion of breast cancer cells during tumor progression.
And, more generally, would it be a problem if the number of solo and small practices dramatically diminished, or even if they mostly disappeared?
Kirsty Rhodes, who was recently diagnosed with a chronic pain condition, told The Independent that her household income dramatically diminished after her husband had to leave work to take care of their children.
When these cells were simultaneously treated with a c-ABL kinase inhibitor, STI571, or a c-ABL-specific siRNA along with adriamycin, the p53-dependent p21 induction was dramatically diminished, even though p53 is substantially induced.
Correspondingly, Bruemmer et al. also have shown that acute macrophage infiltration was dramatically diminished in OPN-null mice compared to wild-type mice in a thioglycollate-induced peritonitis model [ 46].
By late summer, his support among independents, the key factor in his election, had dramatically diminished.
Of course, transparency alone cannot solve complex conflicts, but without it the hope of resolution is dramatically diminished.
The crisis has dramatically diminished the labour market prospects for young people, as many experience long-term unemployment right from the start of their labour market entry, a situation that was never observed during earlier cyclical downturns.
