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The phrase "a dramatically different set" is correct and usable in written English.
It can be used to describe a collection or group that is significantly altered or distinct from another.
Example: "The new policy will create a dramatically different set of expectations for employees compared to the previous guidelines."
Alternatives: "a significantly different group" or "a markedly different collection".
Exact(3)
But drawing on controversies over economic stimulus, bailouts and health legislation, he identified a dramatically different set of villains.
This training program and the subsequent HHC product-development efforts set the stage for the creation of a dramatically different set of personal compacts at Eisai.
A black-white woman has a dramatically different set of experiences and issues than an Asian- Hispanic man.
Similar(57)
This stanza goes on to hold together two dramatically different sets of imagery: war and music.
When I announced that I was leaving Apple to take the reins as CEO of J.C. Penney this month, the business press (and lots of others) began speculating about whether I could replicate the Apple Store's success in such a dramatically different retail setting.
A less aggressive replacement, perhaps from within the financial services industry, could set a dramatically different tone at the agency at a time when it is in the middle of finalizing rules that could reshape parts of the industry.
The European Central Bank was set to tack in a dramatically different direction on monetary policy Thursday by slashing interest rates to help stimulate growth in the buckling euro zone economy.
But meanwhile, its impending passage sets the country on a dramatically different course to the one it's pursued over the last eight years (the last 30, really).
"We don't see it as a dramatically different direction".
But today's indictment tells a dramatically different story.
President Trump has taken a dramatically different path.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com