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This impairment, characterized by a generalized immune activation and a CD4 T-cell depletion has, as consequence among others, a dramatic modification of cytokine and chemokine profiles [22], [23].
Thus, these results have clearly evidenced that the benefit of the multidrug nanoassemblies resulted from a dramatic modification of the pharmacokinetic and biodistribution profiles of the two biologically active compounds, in comparison to their administration just as free drugs.
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Serious clinical complications frequently arise due to dramatic modification of the structural and functional properties of P. falciparum-infected erythrocytes (IEs) [1].
It was a dramatic change of fortune.
The deposition of quartz as pore-filling cement and/or veins is a common diagenetic process during burial sedimentation, and can cause dramatic modifications of bulk-rock mechanics, including changes in stiffness (Laubach et al. 2004), consolidation behavior (Karig and Morgan 1994), and frictional properties (Lockner and Byerlee 1986).
The three bidimensional spectroelectrochemistry signals have demonstrated the occurrence of different types of degradation processes depending on the applied potential, ranging from the simple release of oligomers and hydrolysis products retained in the film during electropolymerization to more dramatic modifications of the film.
Personality in this sense can be lost, what we experience, for instance, in the dramatic modifications of the identity of persons during the pathological processes of frontotemporal dementia or Alzheimer disease [ 46].
The outstanding enrichment difference between all disease variants and noncoding disease variants, occurs within histone modification regions, a dramatic decrease of enrichments, which conversely implies a tight association between histone modification epigenetic marks and disease variants that are located within coding regions.
AZD1152-HQPA treatment resultreatmentdresultedincrease of chromosome number, modramaticon of cell cycle and increasen of apoptosis.
The occurrence of Itai-itai disease in Japan, which affected mainly multiparous postmenopausal women, is a dramatic illustration of this effect modification by calcium and other nutritional deficiencies.
The organization of the anthocyanin inclusions present in BMS35S::R+35S::cellslls undergo dramatic modifications in the presence of light.
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