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The phrase "a dramatic difference in" is correct and usable in written English.
It can be used to describe a significant or noticeable change or variation in a particular aspect or situation.
Example: "There was a dramatic difference in the performance of the team after the new coach was hired."
Alternatives: "a significant change in" or "a striking contrast in".
Exact(60)
Performance improved across all the pharmacies, and customer satisfaction scores rose from 86%to91%1%—a dramatic difference in the aggressive pharmacy market.
The results do not differ substantially given quite a dramatic difference in how dose is coded.
A dramatic difference in dissociation rates was observed between the different species.
"This makes a dramatic difference in terms of lifetime".
Will there be a dramatic difference in the arts under the new administration?
But will any of them make a dramatic difference in the underlying problems?
Just reducing the number of cars by 10percentt would make a dramatic difference in congestion".
Founding location did not seem to make a dramatic difference in performance in our data set.
We saw a dramatic difference in the impact of the two coaching styles.
A dramatic difference in phototoxicity was found: Pd cationic > InCl cationic > Zn cationic > Zn anionic.
Over the years this can make a dramatic difference in your wealth, standard of living in retirement, and so on.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com