Nicholas I. Timko President, New York State Trial Lawyers Association New York, Oct. 21, 2010 To the Editor: There is one rather dramatic deficiency in the argument that Peter Orszag makes, and that is his underlying faith in the efficacy of evidence-based clinical guidelines.
A superfluous preface has been added and the story's dramatic deficiencies, easy to overlook on first viewing, stand exposed.
The development of high-throughput systems for biochemistry and enzymology could have a dramatic impact on this deficiency and would add vitality to these areas of scientific endeavor.
A dramatic example is G6PD deficiency in Tanzania, where prevalence in lowland and highland populations (11.3% and 4.4%, respectively) mirrors that of malaria [ 7].
In MCAD deficiency a dramatic rise of plasma levels of specific free fatty acids is observable, indicating impaired β-oxidation of respective chain-length acyl-CoA.
Already a well-established practice in many developed countries, fortifying flour with iron and folic acid has contributed to a dramatic decrease in micronutrient deficiencies.
This functional specificity was already exemplified in the lymphopoietic system by the genetic mouse models in which Notch1 deficiency results in impaired T-cell development [33], while Notch2 deficiency causes a dramatic absence of MZB cells [34].
Peanut plants subjected to Fe deficiency exhibited a dramatic decrease in net photosynthetic (Pn) and transpiration rates (Tr) by 32.9% and 23.5% compared with EDTA-Fe treatment, whereas Fo, Fv/Fm and ΦPSII also significantly decreased in peanut leaves (Table 3).
However, folate deficiency caused a dramatic increase in the frequency of cranial NTDs in ct/ct embryos to more than 50% (Fig. 3).
