Sentence examples for a dramatic defect from inspiring English sources
Our behavioral experiments showed that feeding inhibition evoked by 1% 1-octanol had a dramatic defect in the ser-2 mutant, which is involved in central integration of feeding (Li et al. 2012).
Thus, although hSgo1-depleted cells had a dramatic defect in the ability to hold sisters together, Rad21-depleted cells did not.
CI performed with the mutant hldA (strain SAL1) produced the lowest CI observed, with a low mean result of 0.005 and a dramatic defect in in vivo survival.
Similar to ICOS−/− mice, ICOSL−/− mice had no defect in naïve cell numbers and a dramatic defect in EM phenotype CD4 T cell numbers (Figure 1C).
We do not see defects in neurogenesis and commitment to neuronal lineages, but find a dramatic defect in the later maturation of neurons after their birth.
In both of these tumor models, deletion of Akt1 resulted in a dramatic defect in tumor induction, while in contrast, tumorigenesis was accelerated in Akt2-deficient mice.
For instance, altered dlx-2a, fgfr1 and axial expression could only be observed in 17/30, 11/30 and 3/30 fmorphantsants, respectively; for neurite branching phenotypes no numbers are given related to the penetrance of the defect; injection of antibodies against alpha-acetylated tubulin resulted in a dramatic axon defect only in 3/30 and axon defasciculation in 13/30 fmr1 morphants.
(c) ATPase-dead K785R mutant (K798R in some citations), a cancer mutation found in the ATP-binding cleft) shows a dramatic dynamic defect, consistent with failure to release immobile chromatin.
When the two inhibitors were combined, each at 100 nM, a dramatic checkpoint defect was exposed.
Video microscopy of the RAP-treated 3D7MSP1flox42C schizonts revealed a dramatic egress defect characterized by abortive erythrocyte membrane rupture and trapping of the merozoites in the partially ruptured cell.
Such a dramatic meiotic defect of dKO has an inevitable consequence of infertility, i.e. all dKO males are sterile, visibly lacking any post meiotic cells in their seminiferous tubules, and with three-fold reduction in total testis size (at the age 6 8 week).
