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The phrase "a dramatic alteration in" is correct and usable in written English.
It can be used when discussing significant changes or transformations in a particular context, such as in a situation, process, or condition.
Example: "The new policy led to a dramatic alteration in the way employees interact with management."
Alternatives: "a significant change in" or "a profound shift in".
Exact(14)
But times have changed, and postdocs have seen a dramatic alteration in their fortunes.
As the RhCC variant localized in rhabdomeres, it implies that the eye phenotype was not due to a dramatic alteration in rhodopsin trafficking.
Following stimulation, these cells undergo a dramatic alteration in their organization.
A dramatic alteration in mate preference was observed (Crews et al. 2007) along with epigenetic alterations (termed epimutations) in the germline (sperm) (Guerrero-Bosagna et al. 2010).
Interestingly, the alteration in GI expression did not result in a dramatic alteration in the timing of the floral induction (Additional file 8).
Analysis of 2-week-old (p14) mMGS-9ANestin animals showed a dramatic alteration in brain morphology with clear signs of spongiosis and robust neuronal PAS staining (Fig 4A).
Similar(46)
In monaural condition, all subjects showed a dramatic alteration ins their abilities to localize a sound source in azimuth.
Substitutions to alanine of four of the five selected amino acids in CRE1/AHK4 showed a dramatic alteration of the cytokinin binding, in this case a strong reduction to total abolishment of the trans-zeatin binding (Fig. 4A), thus confirming their importance in cytokinin binding.
In line with these reports, we found that silencing BAG3 in primary adult human cardiomyocytes results in a dramatic alteration of F-actin filaments.
These changes will lead to a dramatic alteration of the household composition in the near future.
Very little is known about how such a dramatic alteration of the cell cycle in a physiological setting is achieved.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com